Johnson, CM, Grossman, AD. Integrative and Conjugative Elements (ICEs): What They Do and How They Work. Annu. Rev. Genet. 2015;49:577-601 pubmed
Goranov, AI, Katz, L, Breier, AM, Burge, CB, Grossman, AD. A transcriptional response to replication status mediated by the conserved bacterial replication protein DnaA. Proc. Natl. Acad. Sci. U.S.A. 2005;102;12932-7 pubmed
Auchtung, JM, Lee, CA, Monson, RE, Lehman, AP, Grossman, AD. Regulation of a Bacillus subtilis mobile genetic element by intercellular signaling and the global DNA damage response. Proc. Natl. Acad. Sci. U.S.A. 2005;102:12554-9 pubmed
Lemon, KP, Grossman, AD. Localization of bacterial DNA polymerase: evidence for a factory model of replication. Science. 1998;282:1516-9. pubmed
Magnuson, R, Solomon, J, Grossman, AD. Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell. 1994;77:207-16 pubmed
Recent publications
McKeithen-Mead SA, Grossman AD. Timing of integration into the chromosome is critical for the fitness of an integrative and conjugative element and its bacterial host. PLoS Genet. 2023 Feb 13;19(2):e1010524 pubmed
Arbel-Goren R, McKeithen-Mead SA, Voglmaier D, Afremov A, Teza G, Grossman AD, Stavans J. Target search by an imported conjugative DNA element for a unique integration site along a bacterial chromosome during horizontal gene transfer. Nucleic Acid Res. 2023 Apr 24;51(7):3116-3129 pubmed
Schons-Fonseca L, Lazova MD, Smith JL, Grossman AD. Beneficial and detrimental genes in the cellular response to replication arrest. PLoS Genet. 2022 Dec 27;18(12):e1010564 pubmed
Bean EL, McLellan LK, Grossman AD. Activation of the integrative and conjugative element Tn916 causes growth arrest and death of host bacteria. PLoS Genet. 2022 Oct 24;18(10):e1010467 pubmed
McLellan LK, Anderson ME, Grossman AD. TnSmu1 is a functional integrative and conjugative element in Streptococcus mutans that when expressed causes growth arrest of host bacteria. Mol Microbiol. 2022 Dec;118(6):652-669 pubmed
Anderson ME, Smith JL, Grossman AD. Multiple mechanisms for overcoming lethal over-initiation of DNA replication. Mol Microbiol. 2022 Aug 27. doi: 10.1111/mmi.14976. pubmed
Bean EL, Herman C, Anderson ME, Grossman AD. Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species-specific efficiencies. PLoS Genet. 2022 May 18;18(5):e1009998 pubmed
Harden MM, Grossman AD. A CRISPR interference screen reveals a role for cell wall teichoic acids in conjugation in Bacillus subtilis. Mol Microbiol. 2022;00:1-18 pubmed
Johson CM, Harden MM, Grossman AD. Interactions between mobile genetic elements: An anti-phage gene in an integrative and conjugative element protects host cells from predation by a temperate bacteriophage. PLoS Genet. 2022 Feb 14;18(2):e1010065 pubmed
Gallay C, Sanselicio S, Anderson ME, Soh YM, Liu X, Stamsås GA, Pelliciari S, van Raaphorst R, Dénéréaz J, Kjos M, Murray H, Gruber S, Grossman AD, Veening JW. CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA. Nat Microbiol. 2021 Aug pubmed
Davis KP, Grossman AD. Specificity and selective advantage of an exclusion system in the integrative and conjugative element ICEBs1 of Bacillus subtilis. J Bacteriol. 2021 Apr;203(10):e00700-20 pubmed
Jones JM, Grinberg I, Eldar A, Grossman AD. A mobile genetic element increases bacterial host fitness by manipulating development. eLife. 2021 Mar;10:e65924 pubmed
Avello M, Davis KP, Grossman AD. Identification, characterization and benefits of an exclusion system in an integrative and conjugative element of Bacillus subtilis. Mol Microbiol. 2019 Oct;112(4):1066-1082 pubmed
Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol. 2019 Feb;4(2):244-250 pubmed