Key Publications

Johnson, CM, Grossman, AD. Integrative and Conjugative Elements (ICEs): What They Do and How They Work. Annu. Rev. Genet. 2015;49:577-601 pubmed

Goranov, AI, Katz, L, Breier, AM, Burge, CB, Grossman, AD. A transcriptional response to replication status mediated by the conserved bacterial replication protein DnaA. Proc. Natl. Acad. Sci. U.S.A. 2005;102;12932-7 pubmed

Auchtung, JM, Lee, CA, Monson, RE, Lehman, AP, Grossman, AD. Regulation of a Bacillus subtilis mobile genetic element by intercellular signaling and the global DNA damage response. Proc. Natl. Acad. Sci. U.S.A. 2005;102:12554-9 pubmed

Lemon, KP, Grossman, AD. Localization of bacterial DNA polymerase: evidence for a factory model of replication. Science. 1998;282:1516-9. pubmed

Magnuson, R, Solomon, J, Grossman, AD. Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell. 1994;77:207-16 pubmed


Recent publications

Bean EL, Herman C, Anderson ME, Grossman AD. Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species-specific efficiencies. PLoS Genet. 2022 May 18;18(5):e1009998 pubmed

Harden MM, Grossman AD. A CRISPR interference screen reveals a role for cell wall teichoic acids in conjugation in Bacillus subtilis. Mol Microbiol. 2022;00:1-18 pubmed

Bean EL, McLellan LK, Grossman AD. Activation of the integrative and conjugative element Tn916 causes growth arrest and death of host bacteria. biorxiv. 2022 Apr biorxiv

Johson CM, Harden MM, Grossman AD. Interactions between mobile genetic elements: An anti-phage gene in an integrative and conjugative element protects host cells from predation by a temperate bacteriophage. PLoS Genet. 2022 Feb 14;18(2):e1010065 pubmed

Gallay C, Sanselicio S, Anderson ME, Soh YM, Liu X, Stamsås GA, Pelliciari S, van Raaphorst R, Dénéréaz J, Kjos M, Murray H, Gruber S, Grossman AD, Veening JW. CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA. Nat Microbiol. 2021 Aug pubmed

Anderson ME, Smith JL, Grossman AD. Multiple mechanisms for overcoming lethal over-initiation of DNA replication. biorxiv. 2021 May biorxiv

Schons-Fonseca L, Lazova MD, Smith JL, Grossman AD. Beneficial and detrimental genes in the cellular response to replication arrest. biorxiv. 2021 May biorxiv

Davis KP, Grossman AD. Specificity and selective advantage of an exclusion system in the integrative and conjugative element ICEBs1 of Bacillus subtilis. J Bacteriol. 2021 Apr;203(10):e00700-20 pubmed

Jones JM, Grinberg I, Eldar A, Grossman AD. A mobile genetic element increases bacterial host fitness by manipulating development. eLife. 2021 Mar;10:e65924 pubmed

Avello M, Davis KP, Grossman AD. Identification, characterization and benefits of an exclusion system in an integrative and conjugative element of Bacillus subtilis. Mol Microbiol. 2019 Oct;112(4):1066-1082 pubmed

Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol. 2019 Feb;4(2):244-250 pubmed

Brophy JAN, Triassi AJ, Adams BL, Renberg RL, Stratis-Cullum DN, Grossman AD, Voigt CA. Engineered integrative and conjugative elements for efficient and inducible DNA transfer to undomesticated bacteria. Nat Microbiol. 2018 Sep;3(9):1043-1053 pubmed

Washington TA, Smith JL, Grossman AD. Genetic networks controlled by the bacterial replication initiator and transcription factor DnaA in Bacillus subtilis. Mol Microbiol. 2017 Oct;106(1):109-128 pubmed

Seid CA, Smith JL, Grossman AD. Genetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis. Mol Microbiol. 2017;103(5):798-817 pubmed

Wright LD, Grossman AD. Autonomous Replication of the Conjugative Transposon Tn 916. J Bacteriol. 2016;198(24):3355-3366 pubmed

Johnson CM, Grossman AD. The Composition of the Cell Envelope Affects Conjugation in Bacillus subtilis. J Bacteriol. 2016;198(8):1241-1249 pubmed

Johnson CM, Grossman AD. Identification of host genes that affect acquisition of an integrative and conjugative element in Bacillus subtilis. Mol Microbiol. 2015;98(6):1222-1222 pubmed